A 3D-printed Sn-doped calcium phosphate scaffold for bone tissue engineering

Recent developments in 3D printing technology have been applied the field of tissue engineering to fabricate customized bone repair scaffolds. β-tricalcium phosphate (β-TCP) is a bioceramic material with excellent potential as scaffold foundation. Doping metallic ions β-TCP will significantly enhance mechanical property and regeneration performance compared pure specimens. In this study, we proposed protocol for fabrication Sn-doped (Sn@TCP) using technology, effect Sn-doping on physicochemical properties its vitro bioactivity were investigated. Polyethylene glycol polyvinyl alcohol used binder construct Sn@TCP scaffolds which good biocompability can break down into H 2 O CO after sintering. The appearance constructed by closely matched computer design. incorporation Sn improved compressive strength scaffold. Moreover, retained inherently biocompatibility exhibited better osteoinduction capability than Notably, ability dependent content. conclusion, enhanced osteoblast-inducing activity show great promise materials applications.